Studies on the synthesis of nucleotidyl-peptides. II. The preparation of a nucleoidyl-peptide haVING A 5'-nucleotidyl-(p-o)-serine phosphodiester bond | Zendy

Yoshihito Ueno | Zendy; Ryuichi Saito | Zendy; Tsuijiki Hata | Zendy

Open Access

Studies on the synthesis of nucleotidyl-peptides. II. The preparation of a nucleoidyl-peptide haVING A 5'-nucleotidyl-(p-o)-serine phosphodiester bond

Author(s) -

Yoshihito Ueno,

Ryuichi Saito,

Tsuijiki Hata

Publication year - 1993

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/21.19.4451

Subject(s) - phosphodiester bond , biology , serine , peptide , biochemistry , microbiology and biotechnology , phosphorylation , stereochemistry , rna , gene , chemistry

The preparation of a nucleotidyl-peptide having a thymidine-5'-yl-(P-O)-serine phosphodiester bond, [H-Ala-Ser(pTpT)-Phe-OH](24) is described. After condensation between the phosphorylated peptide component and an oligonucleotide component, all protecting groups could be removed under neutral conditions without beta-elimination of the pTpT from the serine moiety.

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