Open AccessStructure and mapping of thefosB gene. FosB downregulates the activity of thefosB promotero
Author(s) -
Pedro S. Lazo,
K Dorfman,
Tetsuro Noguchi,
MarieGeneviève Mattéi,
Rodrigo Bravo
Publication year - 1992
Publication title -
nucleic acids research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 9.008
H-Index - 537
eISSN - 1362-4954
pISSN - 0305-1048
DOI - 10.1093/nar/20.2.343
Subject(s) - biology , fosb , genetics , gene , microbiology and biotechnology , gene expression
We have determined the genomic structure of the fosB gene and shown that it consists of 4 exons and 3 introns at positions also found in the c-fos gene. By deletion analysis we have characterized a region upstream of the TATA box which is the promoter region of the gene. Several consensus sequences have been identified, including an SRE and AP-1 binding site whose relative positions are identical to those in the 5' upstream region of the c-fos gene. We have also shown that FosB and c-Fos can downregulate the activity of the fosB promoter to a similar extent. The fosB gene is located in the [A1-B1] region of mouse chromosome 7.