A novel POU homeodomain gene specifically expressed in cells of the developing mammalian nervous system | Zendy

Robert G. Collum | Zendy; Peter Fisher | Zendy; Milton W. Datta | Zendy; Scott Mellis | Zendy; Carol J. Thiele | Zendy; Kay Huebner | Zendy; Carlo M. Croce | Zendy; Mark A. Israel | Zendy; Thomas Theil | Zendy; Tarik Morory | Zendy; Ronald A. DePinho | Zendy; Frederick W. Alt | Zendy

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A novel POU homeodomain gene specifically expressed in cells of the developing mammalian nervous system

Author(s) -

Robert G. Collum,

Peter Fisher,

Milton W. Datta,

Scott Mellis,

Carol J. Thiele,

Kay Huebner,

Carlo M. Croce,

Mark A. Israel,

Thomas Theil,

Tarik Morory,

Ronald A. DePinho,

Frederick W. Alt

Publication year - 1992

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/20.18.4919

Subject(s) - pou domain , biology , homeobox , gene , nervous system , microbiology and biotechnology , genetics , gene expression , neuroscience

We report the isolation of a novel human POU domain encoding gene named RDC-1. The POU domain of the RDC-1 encoded protein is highly related to the POU domain potentially encoded by the rat brain-3 sequence and to that of the Drosophila I-POU protein; outside of the POU region, RDC-1 is unrelated to any previously characterized protein. The RDC-1 gene is expressed almost exclusively in normal tissues and transformed cells of neural origin. In the developing mouse and human fetus, RDC-1 is expressed in a spatially and temporally restricted pattern that suggests a critical role in the differentiation of neuronal tissues. In addition, RDC-1 is expressed in a unique subset of tumors of the peripheral nervous system including neuroepitheliomas and Ewing's sarcomas but not neuroblastomas. Based on its unique structural characteristics and expression pattern, we discuss potential functions for the RDC-1 protein.

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