m7G5′ppp5′GmpCpUp at the 5′ terminus of reovirus messenger RNA | Zendy

Manny Faust | Zendy; Kenneth E.M. Hastings | Zendy; S. Milward | Zendy

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m⁷G^5′ppp^5′GmpCpUp at the 5′ terminus of reovirus messenger RNA

Author(s) -

Manny Faust,

Kenneth E.M. Hastings,

S. Milward

Publication year - 1975

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/2.8.1329

Subject(s) - guanosine , biology , messenger rna , rna , microbiology and biotechnology , nucleotide , polyadenylation , methionine , guanosine triphosphate , biochemistry , amino acid , gene

In the presence of S-adenosyl methionine the 5' terminal guanosine residue of in vitro synthesized reovirus mRNA becomes methylated at the 2'-OH position. In addition, 7-methyl guanylic acid is condensed covalently at the 5' terminus resulting in the formation of a 5' to 5' triphosphate bridge. Analysis of the 5' terminal sequence of methylated reovirus mRNA revealed that it has the structure m7G5'ppp5'GmpCpUp.

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