Metal ion-mediated specific interactions between nucleic add bases of polynucleotides and amino acid side chains of polypeptides. | Zendy

Claude Hélène | Zendy

Open Access

Metal ion-mediated specific interactions between nucleic add bases of polynucleotides and amino acid side chains of polypeptides.

Author(s) -

Claude Hélène

Publication year - 1975

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/2.6.961

Subject(s) - polynucleotide , nucleic acid , biology , metal , amino acid , rna , side chain , biochemistry , chemistry , gene , organic chemistry , polymer

Interactions between copolypeptides containing Glu and Tyr residues and polynucleotides can be mediated through divalent metal ions such as Zn-2+ and Ci-2+. Circular dichroism studies show that the binding of metal ion - polypeptide complexes to poly(A) induces an unstacking of adenine bases. Fluorescence investigations demonstrate that Tyrosine - Adenine interactions result from the formation of ternary complexes polypeptide-Zn-2 plus-polynucleotide.

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