Construction of a double-stranded deoxyribonucleotide sequence of 45 base pairs designed to code for S-peptide2-14of bovine ribonuclease A | Zendy

Clifford L. Harvey | Zendy; Katherine S. Olson | Zendy; Alice De Czekala | Zendy; A. L. Nussbaum | Zendy

Open Access

Construction of a double-stranded deoxyribonucleotide sequence of 45 base pairs designed to code for S-peptide_2-14of bovine ribonuclease A

Author(s) -

Clifford L. Harvey,

Katherine S. Olson,

Alice De Czekala,

A. L. Nussbaum

Publication year - 1975

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/2.11.2007

Subject(s) - biology , deoxyribonucleotide , ribonuclease , duplex (building) , dna , base pair , sequence (biology) , peptide , monomer , oligonucleotide , microbiology and biotechnology , biochemistry , genetics , rna , polymer , gene , chemistry , organic chemistry

An artificial DNA duplex, each strand consisting of 45 monomers, is constructed from chemically synthesized deoxyriboöligonucleotides. The resulting bihelical polymer may code for a modified S-peptide of Ribonuclease A. This is the first synthetic duplex designed to code for a eukaryotic message.

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