An erythroid specific enhancer upstream to the gene encodin the cell-type specific transcription factor GATA-1 | Zendy

Silvia K. Nicolis | Zendy; C Bertini | Zendy; Antonella Ronchi | Zendy; Stefania Crotta | Zendy; Luisa Lanfranco | Zendy; Emanuela Moroni | Zendy; Barbára Giglioni | Zendy; Sergio Ottolenghi | Zendy

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An erythroid specific enhancer upstream to the gene encodin the cell-type specific transcription factor GATA-1

Author(s) -

Silvia K. Nicolis,

C Bertini,

Antonella Ronchi,

Stefania Crotta,

Luisa Lanfranco,

Emanuela Moroni,

Barbára Giglioni,

Sergio Ottolenghi

Publication year - 1991

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/19.19.5285

Subject(s) - biology , enhancer , transcription factor , genetics , gene , gata transcription factor , transcription (linguistics) , gata2 , microbiology and biotechnology , gene expression , promoter , linguistics , philosophy

The transcription factor GATA-1 is expressed in a subset of hemopoietic cells, where it mediates the cell-type specific expression of several genes. We have cloned the mouse and human GATA-1 genes. A region upstream to the first exon, and highly conserved between mouse and man, acts as an erythroid specific enhancer in transient assays, if linked to the GATA-1 or to the SV40 promoter. The activity of the enhancer is almost completely dependent on the integrity of a dimeric GATA-1 binding site.

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