EcoRIPolymorphism in the human third complement compenent (C3) gene | Zendy

Marina Botto | Zendy; Kok Yong Fong | Zendy; A K So | Zendy

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EcoRIPolymorphism in the human third complement compenent (C3) gene

Author(s) -

Marina Botto,

Kok Yong Fong,

A K So

Publication year - 1990

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/18.9.2833

Subject(s) - library science , medical school , unit (ring theory) , family medicine , medicine , medical education , psychology , computer science , mathematics education

Source/Description A cDNA fragment, pC3.11 (1) was used as probe. Polymorphisms: EcoRI cleavage of genomic DNA reveals a 2 allele polymorphism with band sizes of 5.2 and 5.6 kb. Invariant bands of 11.5, 11.0, 9.0 and 3 0 kb were also present. Frequency: Estimated from 35 unrelated Caucasians. Allele Frequency Dl 5.2 0.67 D2 5.6 0.33 Chromosomal Localisation: The human C3 gene had been assigned to chromocome 19 pl3.3-pl3.2 (2). Mendelian Inheritance: Co-dominant inheritance was documented in one family with 8 individuals.

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