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Prediction of oligonucleotide frequencies based upon dinucleotide frequencies obtained from the nearest neighbor analysis
Author(s) -
Juan Hong
Publication year - 1990
Publication title -
nucleic acids research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 9.008
H-Index - 537
eISSN - 1362-4954
pISSN - 0305-1048
DOI - 10.1093/nar/18.6.1625
Subject(s) - biology , k nearest neighbors algorithm , markov chain , oligonucleotide , biological system , pattern recognition (psychology) , computational biology , genetics , statistics , artificial intelligence , computer science , mathematics , dna
A statistical method of predicting hexanucleotide frequencies is presented. The method requires dinucleotide frequencies which can be readily obtained by nearest neighbor analysis. The frequencies of 64 hexanucleotides of E. coli were estimated and compared well with those predicted by a third order Markov chain.

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