Open AccessSynthesis and enzymatic polymerisation of 5-amino-1-(2′-deoxy-β-D-ribofuranosyl)imidazole-4-carboxamide-5′-triphosphate
Author(s) -
Sylvie Pochet,
Richard D’Ari
Publication year - 1990
Publication title -
nucleic acids research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 9.008
H-Index - 537
eISSN - 1362-4954
pISSN - 0305-1048
DOI - 10.1093/nar/18.23.7127
Subject(s) - imidazole , biology , carboxamide , adenosine triphosphate , derivative (finance) , enzyme , biochemistry , stereochemistry , microbiology and biotechnology , chemistry , financial economics , economics
The chemical synthesis of 5-amino-1-(2'-deoxy-beta-D-ribofuranosyl)imidazole-4-carboxamide, referred to as dZ, and of its 5'-triphosphate derivative (dZTP), from 2'-deoxyinosine is described. The polymerisation of dZTP using terminal deoxynucleotidyltransferase to give a homopolymer is also presented.