Synthesis and enzymatic polymerisation of 5-amino-1-(2′-deoxy-β-D-ribofuranosyl)imidazole-4-carboxamide-5′-triphosphate | Zendy

Sylvie Pochet | Zendy; Richard D’Ari | Zendy

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Synthesis and enzymatic polymerisation of 5-amino-1-(2′-deoxy-β-D-ribofuranosyl)imidazole-4-carboxamide-5′-triphosphate

Author(s) -

Sylvie Pochet,

Richard D’Ari

Publication year - 1990

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/18.23.7127

Subject(s) - imidazole , biology , carboxamide , adenosine triphosphate , derivative (finance) , enzyme , biochemistry , stereochemistry , microbiology and biotechnology , chemistry , financial economics , economics

The chemical synthesis of 5-amino-1-(2'-deoxy-beta-D-ribofuranosyl)imidazole-4-carboxamide, referred to as dZ, and of its 5'-triphosphate derivative (dZTP), from 2'-deoxyinosine is described. The polymerisation of dZTP using terminal deoxynucleotidyltransferase to give a homopolymer is also presented.

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