A negative regulatory element in the promoter of the human α1-antitrypsin gene | Zendy

Vincenzo De Simone | Zendy; Riccardo Cortese | Zendy

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A negative regulatory element in the promoter of the human α1-antitrypsin gene

Author(s) -

Vincenzo De Simone,

Riccardo Cortese

Publication year - 1989

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/17.22.9407

Subject(s) - biology , heterologous , promoter , gene , negative regulatory element , regulatory sequence , response element , microbiology and biotechnology , transcription (linguistics) , regulation of gene expression , dna , genetics , gene expression , linguistics , philosophy

A "minimal tissue-specific element" of the human alpha 1-antitrypsin (alpha 1-AT) gene promoter, located in the -137/-37 region, is able to drive hepatoma-specific transcription from the heterologous SV40 promoter. Here we show that, in HeLa cells, this element is inactivated by a negative regulatory mechanism. This negative control can be overcome by deletion or mutation of two specific DNA domains.

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