DNA curvature in front of the human mitochondrial L-strand replication origin with specific protein binding | Zendy

Ronald Welter | Zendy; Steven Dooley | Zendy; K. D. Zang | Zendy; Blin Nikolaus | Zendy

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DNA curvature in front of the human mitochondrial L-strand replication origin with specific protein binding

Author(s) -

Ronald Welter,

Steven Dooley,

K. D. Zang,

Blin Nikolaus

Publication year - 1989

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/17.15.6077

Subject(s) - biology , replication protein a , dna replication , mitochondrial dna , eukaryotic dna replication , dna , d loop , genetics , control of chromosome duplication , dna clamp , hmg box , microbiology and biotechnology , dna binding protein , gene , rna , transcription factor , reverse transcriptase

DNA bending has been suggested to play a role in the regulation of gene expression, initiation of DNA-replication, site specific recombination, and DNA packaging. In the human mitochondrial DNA we have found a DNA curvature structure within the 3'-region of ther URF2 sequence in front of the L-strand origin of replication. This structure interacts specifically with a protein factor isolated from mitochondria. Based on the localization of this DNA curvature structure and the known function of such structures the data suggest a model in which this DNA signal sequence and its specific protein binding is involved in the regulatory initiation event of L-strand replication.

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