Open AccessSequences flanking the repeat arrays of human minlsatellites: association with tandem and dispersed repeat elements
Author(s) -
John A.L. Armour,
Zilla Wong,
Victoria Wilson,
Nicola J. Royle,
Alec J. Jeffreys
Publication year - 1989
Publication title -
nucleic acids research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 9.008
H-Index - 537
eISSN - 1362-4954
pISSN - 0305-1048
DOI - 10.1093/nar/17.13.4925
Subject(s) - biology , tandem repeat , genetics , 5' flanking region , tandem , base sequence , computational biology , association (psychology) , evolutionary biology , dna , gene , genome , promoter , philosophy , gene expression , materials science , epistemology , composite material
We present DNA sequences flanking cloned hypervariable human minisatellites. In addition to providing confirmatory evidence that minisatellites cluster with other tandem repeats, these flanking sequences contain a high frequency of interspersed repetitive elements. These elements include a retroviral LTR-like sequence, from which one of the minisatellites appears to have expanded, and a recently described short interspersed repeat. We present our own findings concerning this element, in particular that those examples studied do not show significant evolutionary conservation, despite suggestions that the element may have a cis-acting function.