Isolation of theXenopusbomolog ofint-1/winglessand expression during neurula stages of early development | Zendy

Jasprien Noordermeer | Zendy; Frits Meijlink | Zendy; Peter Verrijzer | Zendy; Frans A.M. Rijsewijk | Zendy; Olivier Destrée | Zendy

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Isolation of theXenopusbomolog ofint-1/winglessand expression during neurula stages of early development

Author(s) -

Jasprien Noordermeer,

Frits Meijlink,

Peter Verrijzer,

Frans A.M. Rijsewijk,

Olivier Destrée

Publication year - 1989

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/17.1.11

Subject(s) - biology , xenopus , neurula , complementary dna , microbiology and biotechnology , conserved sequence , peptide sequence , genetics , gene , embryogenesis , gastrulation

We have isolated the Xenopus homolog (Xint-1) of the mouse protooncogene int-1 from a neurula stage 17 cDNA library. The deduced protein sequence of Xint-1 includes 371 amino acids. The Xint-1 protein is more similar to the mammalian int-1 product (69%), than to the Drosophila counterpart of int-1, wingless (50%). Xint-1 shares several characteristics of secreted proteins with the other int-1 homologs: it has a hydrophobic leader, multiple conserved potential N-linked glycosylation sites and is rich in cysteine residues. All 23 cysteines are conserved in the three proteins. Xint-1 is transiently expressed during the neurula stages of early Xenopus development.

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