Adenoslne deaminase gene expression is regulated posttranscriptionally in the nucleus | Zendy

Th.M. Berkvens | Zendy; F. Schoute | Zendy; H. van Ormondt | Zendy; P. Meera Khan | Zendy; A.J. van der Eb | Zendy

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Adenoslne deaminase gene expression is regulated posttranscriptionally in the nucleus

Author(s) -

Th.M. Berkvens,

F. Schoute,

H. van Ormondt,

P. Meera Khan,

A.J. van der Eb

Publication year - 1988

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/16.8.3255

Subject(s) - biology , microbiology and biotechnology , housekeeping gene , adenosine deaminase , nucleus , gene expression , messenger rna , cell culture , gene , housekeeping , enzyme , biochemistry , genetics

The housekeeping enzyme adenosine deaminase (ADA) shows a large variation in tissue-specific expression ranging from 1 Iu in red blood cells to 880 Iu in thymocytes. We investigated the acute lymphocytic leukemic cell line Molt-4 (660 Iu ADA/g protein) and the promyelocytic cell line HL-60 (38 Iu ADA/g protein) as a model system to determine the levels at which the tissue-specific expression of ADA is regulated. From our results it can be concluded that the almost 20-fold difference in ADA expression between Molt-4 and HL-60 is the result of differences in the post-transcriptional processing and/or stability of ADA pre-mRNA within the nucleus.

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