Computer simulation of DNA ligation: determination of initial DNA concentrations favouring the formation of recombinant molecules | Zendy

Frédéric Dardel | Zendy

Open Access

Computer simulation of DNA ligation: determination of initial DNA concentrations favouring the formation of recombinant molecules

Author(s) -

Frédéric Dardel

Publication year - 1988

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/16.5.1779

Subject(s) - microcomputer , biology , dna , recombinant dna , ligation , range (aeronautics) , algorithm , biological system , computer science , computational biology , database , genetics , microbiology and biotechnology , materials science , telecommunications , chip , gene , composite material

A program is described which aligns pairs of linear restriction site maps using an algorithm which maximizes the number of coincident sites through the addition of extra 'padding' fragments; and makes maps of the non-conserved sites between pairs and triplets of input maps. A range of display facilities, hardcopy functions and database management routines are also included. The program runs on a stand-alone microcomputer, and is stored along with a database of several hundred files on a single floppy disc.

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