Open AccessObjective comparison of exon and intron sequences by the mean of 2-dimensional data analysis methods
Author(s) -
Lydie Bougueleret,
Fredj Tekaia,
Isabelle Sauvaget,
JeanMichel Claverie
Publication year - 1988
Publication title -
nucleic acids research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 9.008
H-Index - 537
eISSN - 1362-4954
pISSN - 0305-1048
DOI - 10.1093/nar/16.5.1729
Subject(s) - biology , intron , exon , genetics , context (archaeology) , oligonucleotide , sequence analysis , rna , sequence (biology) , computational biology , nucleic acid , cpg site , gene , evolutionary biology , paleontology , gene expression , dna methylation
Here we advocate the use of 2-dimensional data representation in the context of the informational approach of sequence analysis (Claverie & Bougueleret (1986) Nucleic Acids Research 14, 179-196) by applying these methods to the problem of intron/exon discrimination. Two main findings are reported: i) oligonucleotide patterns complementary to the Ul small nuclear RNA are specifically avoided in exon sequences, ii) vertebrate intron sequences, to the exclusion of other eukaryotic phyla, are characterized by a peculiar distribution of CpG containing patterns.