Synthesis of nuclelc acid methylphosphonothloates | Zendy

H. C. P. F. ROELEN | Zendy; Erik de Vroom | Zendy; G.A. van der Marel | Zendy; Jacques H. van Boom | Zendy

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Synthesis of nuclelc acid methylphosphonothloates

Author(s) -

H. C. P. F. ROELEN,

Erik de Vroom,

G.A. van der Marel,

Jacques H. van Boom

Publication year - 1988

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/16.15.7633

Subject(s) - biology , diastereomer , reagent , uridine , dimer , stereochemistry , combinatorial chemistry , biochemistry , rna , organic chemistry , chemistry , gene

The reagent obtained in situ by treating methylphosphonothioic dichloride with 1-hydroxy-6-trifluoromethylbenzotriazole could be used for the introduction of methylphosphonothioate linkages. The individual diastereomers of the protected dimer d-Tp(S,Me)A were applied in the synthesis of the chiral pure (R or S) hexamers d-[CpCpTp(S,Me)ApGpG]. The reagent showed also to be very effective for the preparation of the 3',5'-cyclic methylphosphonothioate of uridine.

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