Open AccessChromosome size polymorphism inPlasmodium falciparumcan involve deletions of the subtelomeric pPFrep20 sequence
Author(s) -
Jintana Patarapotikul,
Gordon Langsley
Publication year - 1988
Publication title -
nucleic acids research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 9.008
H-Index - 537
eISSN - 1362-4954
pISSN - 0305-1048
DOI - 10.1093/nar/16.10.4331
Subject(s) - biology , subtelomere , genetics , plasmodium falciparum , chromosome , repeated sequence , microbiology and biotechnology , gene , genome , malaria , immunology
The P. falciparum pPFrep20 repetitive element from the Palo Alto Uganda strain has been isolated and sequenced. The Palo Alto pPFrep20 repeat (pPFPArep20) has a clustered subtelomeric location and on chromosome 1 has been deleted from one end. Analysis of chromosome 1 from 5 other strains has revealed that pPFrep20 sequences have been deleted from one end in 3 of them. Thus, deletion of pPFrep20 appears to be a frequent event that could significantly contribute to chromosome size polymorphism in P. falciparum.