DNA sequence preferences for an intercalating porphyin compound revealed by footprinting | Zendy

Kevin G. Ford | Zendy; Keith R. Fox | Zendy; Stephen Neidle | Zendy; Michael J. Waring | Zendy

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DNA sequence preferences for an intercalating porphyin compound revealed by footprinting

Author(s) -

Kevin G. Ford,

Keith R. Fox,

Stephen Neidle,

Michael J. Waring

Publication year - 1987

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/15.5.2221

Subject(s) - library science , biology , classics , history , computer science

The DNA sequence preferences of the compound meso-tetra-(4-N-methyl(pyridyl) porphyrin and its nickel complex have been investigated by means of footprinting experiments on several DNA fragments, using DNAase I and micrococcal nuclease as footprinting agents. A complex pattern of both AT and GC-protected sites was found. Ligand-induced long-range conformational changes were inferred in several instances to be related to the observed large-scale blockages of enzymatic cutting.

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