cDNA and deduced amino acid sequence ofDrosophilarp21C, another ‘A’-type ribosomal protein

The nucleotlde and deduced amino acid sequence of a Drosophila melanogaster cDNA which hybridizes in situ to cytogenetlc region 21C Is reported (Fig. la.). The deduced protein shares functional homology with other eukaryotic members of the "A n-type ribosomal protein (rp) family (1,2). rp21C contains an ORP of 336 nt. which codes for a highly negatively charged protein that includes sequential stretches of hydrophoblc and hydrophllle residues at the carboxy-terminus. Using the UWGCG BESTPIT program, 66 and 7658 nt. identity exists respectively between the coding regions of rp2lC and those of Artemla sallna e U 2 ' (3) and Drosophlla rpAl W. An 80# nt. Identity also appears within a 15 nt. region extending from-4? to-32 relative to the translatlonal start site of both rpAl and rp2lC (Fig. lb.). Recently, several non-ldentlcal crosshybrldlzlng cDNA and genomic clones have been Isolated in an attempt to Identify other members of this putative "A"-type ribosomal protein gene family in Drosophila.