Open AccessUnusual features of CpG-rich (HTF) Islands in the human α globin complex: association with non-functional pseudogenes and presence within the 3′ portion of the ζ gene
Author(s) -
Nathan FischelGhodsian,
Robert D. Nicholls,
Douglas R. Higgs
Publication year - 1987
Publication title -
nucleic acids research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 9.008
H-Index - 537
eISSN - 1362-4954
pISSN - 0305-1048
DOI - 10.1093/nar/15.22.9215
Subject(s) - pseudogene , biology , gene , genetics , globin , cpg site , computational biology , microbiology and biotechnology , genome , gene expression , dna methylation
We have characterised a cluster of CpG rich (HTF) islands in the alpha-globin complex and report here two unusual features: The human embryonic zeta 2-globin gene is associated with an HTF island within its 3' portion rather than at the 5' end. Furthermore at least two non-functional pseudogenes within the cluster (psi zeta 1 and psi alpha 2) are associated with CpG rich islands.