Analysis of conformational parameters in nucleic acid fragments. I. Single crystals of nucleosides and nucleotides | Zendy

Chick C. Wilson | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Analysis of conformational parameters in nucleic acid fragments. I. Single crystals of nucleosides and nucleotides

Author(s) -

Chick C. Wilson

Publication year - 1987

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/15.21.8577

Subject(s) - buckle , nucleotide , twist , propeller , base (topology) , hydrogen bond , nucleic acid , biology , crystallography , base pair , helix (gastropod) , stereochemistry , geometry , dna , chemistry , molecule , materials science , biochemistry , mathematics , ecology , mathematical analysis , organic chemistry , marine engineering , snail , gene , engineering , composite material

A study has been undertaken of conformational parameters in single crystal structures of nucleosides and nucleotides using the techniques of helical conformational analysis. A "quasi-helix" was generated from the geometry of base-paired structures, using published data extracted from the Cambridge structural database. A total of 54 base-pairs were found in these structures, for each of which were calculated hydrogen bond parameters, propeller twist, buckle and C1'-C1' separations. These were analysed according to various classifications. Propeller twists are found to show a wide range of values and the magnitude of twist appears to be unrelated to hydrogen bond parameters or C1'-C1' separation. The values of the buckle parameter vary over a smaller range of values and are unrelated to propeller twist magnitude. There is found to be a greater tendency to form homo-base-pairs among compounds containing adenine bases.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research