Escherichia coli repgene: sequence of the gene, the encoded helicase, and its homology withuvrD* | Zendy

Carol A. Gilchrist | Zendy; David T. Denhardt | Zendy

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Escherichia coli repgene: sequence of the gene, the encoded helicase, and its homology withuvrD^*

Author(s) -

Carol A. Gilchrist,

David T. Denhardt

Publication year - 1987

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/15.2.465

Subject(s) - biology , homology (biology) , helicase , gene , genetics , nucleic acid sequence , microbiology and biotechnology , open reading frame , peptide sequence , escherichia coli , dna , gene product , rna helicase a , protein primary structure , gene expression , rna

The sequence of a 2.67-kilobase section of the Escherichia coli chromosome that contains the rep gene has been determined. This gene codes for a protein of predicted Mr 72,800, a DNA helicase, which is also a single-stranded DNA-dependent ATPase. The sequenced region contains an open reading frame of the correct length and orientation to encode the Rep protein. A secondary structure for the protein can be formulated from the amino acid sequence. We have compared both the primary and the secondary structures of Rep with other proteins and find the greatest homology between Rep and E. coli helicase II, the product of the uvrD gene.

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