Vacuum UV circular dichroism is diagnostic for the left-handed Z form of poly (d(A-C-d).d(G-D) and other potydeoxynudeotides | Zendy

Jeannine H. Riazance | Zendy; W. Curtis Johnson | Zendy; Lawrence P. McImosh | Zendy; Thomas M. Jovin | Zendy

Open Access

Vacuum UV circular dichroism is diagnostic for the left-handed Z form of poly (d(A-C-d).d(G-D) and other potydeoxynudeotides

Author(s) -

Jeannine H. Riazance,

W. Curtis Johnson,

Lawrence P. McImosh,

Thomas M. Jovin

Publication year - 1987

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/15.18.7627

Subject(s) - circular dichroism , wavelength , left handed , crystallography , polymer , spectral line , physics , optics , nuclear magnetic resonance , chemistry , astronomy

Circular dichroism spectra are extended into the vacuum UV to about 178 nm for four polydeoxynucleotides of various sequences capable of assuming the left-handed Z form. It is found that each of these polymers, including those with brominated bases and those with the four different bases, have a characteristic negative feature at short wavelengths when in the Z form. In contrast, the B form only has a positive band between 180 and 200 nm. Furthermore, a blue shift of the short wavelength crossover is diagnostic of the B- to Z-form transition for all polymers studied so far. These results confirm that poly[d(A-C).d(G-T)] can assume the Z form in solution at low concentration.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research