Open AccessA new repetitive element of the CRI family downstream of the chicken vitellogenin gene
Author(s) -
F. Van Het Schip,
John Samallo,
Frits Meijlink,
M. Gruber,
Geert Ab
Publication year - 1987
Publication title -
nucleic acids research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 9.008
H-Index - 537
eISSN - 1362-4954
pISSN - 0305-1048
DOI - 10.1093/nar/15.10.4193
Subject(s) - biology , repeated sequence , gene , vitellogenin , genetics , chromatin , sequence (biology) , hormone response element , dna , microbiology and biotechnology , regulatory sequence , regulation of gene expression , genome , cancer , estrogen receptor , breast cancer
We have analyzed a repetitive DNA sequence found in the 3'-flanking region of the chicken vitellogenin gene. By its sequence, the repetitive DNA has been identified as a hitherto unreported member of the chicken CR1 family of repetitive elements. The CR1 sequence displays the structural characteristics of a long terminal repeat located at the 3' end of an avian retrovirus. The CR1 element lies 2.2 kb downstream of the vitellogenin gene and 'points' away from the gene rather than toward it. In this respect, this element differs from other CR1 repeats. The CR1 element is embedded in a region showing changes in chromatin structure implying a potential role for this sequence in determining the structural state of the local chromatin.