NMR, CD and IR spectroscopies of a tridecanucieotide containing a no-base residue: coexistence of B and Z conformations | Zendy

Sylvie Pochet | Zendy; T. HuynhDinh | Zendy; JeanMichel Neumann | Zendy; S. TranDinh | Zendy; S. Adam | Zendy; J. Taboury | Zendy; E. Taillandier | Zendy; Jean Igolen | Zendy

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NMR, CD and IR spectroscopies of a tridecanucieotide containing a no-base residue: coexistence of B and Z conformations

Author(s) -

Sylvie Pochet,

T. HuynhDinh,

JeanMichel Neumann,

S. TranDinh,

S. Adam,

J. Taboury,

E. Taillandier,

Jean Igolen

Publication year - 1986

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/14.2.1107

Subject(s) - oligomer , residue (chemistry) , ap site , biology , dna , nuclear magnetic resonance spectroscopy , stereochemistry , crystallography , biochemistry , materials science , dna damage , chemistry , polymer chemistry

The synthesis of the tridecadeoxynucleotide d(CGm5CGCGxACATGT), where x is the 1-cyano-2-deoxy-beta-D-erythropentofuranose, is described. The NMR, IR, CD studies at various salt concentrations and temperatures of this oligomer show that the B and Z conformations are simultaneously present in the same short DNA fragment. A single apurinic residue is sufficient for the coexistence of the B and Z helices on this oligomer.

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