Characterization of a mitochondrial protein binding to single-stranded DNA | Zendy

Bernard Mignotte | Zendy; Monique Barat | Zendy; JeanClaude Mounolou | Zendy

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Characterization of a mitochondrial protein binding to single-stranded DNA

Author(s) -

Bernard Mignotte,

Monique Barat,

JeanClaude Mounolou

Publication year - 1985

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/13.5.1703

Subject(s) - biology , polynucleotide , dna , hmg box , single stranded binding protein , xenopus , dna binding protein , biochemistry , mitochondrial dna , base pair , microbiology and biotechnology , genetics , gene , transcription factor

A DNA-binding protein from Xenopus laevis oocyte mitochondria which has been found associated with the D-loop also shows a strong preference for single-stranded DNA. The binding to polynucleotides is dependent on the base composition, but no sequence specificity was found. This protein, called mtSSB, binds tightly and cooperatively to single-stranded DNA. By its amino-acid composition and its binding properties it appears to be similar to the single-stranded DNA-binding proteins found in prokaryotes.

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