Open AccessYeast mitochondrial tRNAIleand tRNAmMet: nucleotide sequence and codon recognition patterns
Author(s) -
Annie-Paule Sibler,
G. Dirheimer,
Robert P. Martin
Publication year - 1985
Publication title -
nucleic acids research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 9.008
H-Index - 537
eISSN - 1362-4954
pISSN - 0305-1048
DOI - 10.1093/nar/13.4.1341
Subject(s) - transfer rna , biology , nucleic acid sequence , nucleotide , genetics , yeast , base pair , genetic code , mitochondrial dna , sequence (biology) , microbiology and biotechnology , gene , rna
The nucleotide sequence of yeast mitochondrial isoleucine- and methionine-elongator tRNA have been determined. Interestingly, long stretches of almost identical nucleotide sequences are found within these two tRNAs and also within the yeast mt tRNAMetf, suggesting that the 3 tRNAs may have arisen from a common ancestor. Both mt tRNAMetm and tRNAIle contain all the structural characteristics which are present in the standard cloverleaf, except that the mt tRNAMetm contains an extra unpaired nucleotide within the base-paired T psi C stem. This rather unusual feature may have an influence on the decoding properties of the C-A-U anticodon of mt tRNAMetm by conferring the ability to translate not only the codon A-U-G but also A-U-A.