Detailed analysis of the mRNAs mapping in the short unique region of herpes simplex virus type 1 | Zendy

Frazer J. Rixon | Zendy; Duncan J. McGeoch | Zendy

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Detailed analysis of the mRNAs mapping in the short unique region of herpes simplex virus type 1

Author(s) -

Frazer J. Rixon,

Duncan J. McGeoch

Publication year - 1985

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/13.3.953

Subject(s) - biology , herpes simplex virus , gene , genome , coding region , genetics , sequence (biology) , virus , sequence analysis , messenger rna , dna , microbiology and biotechnology , virology

We have analysed the mRNAs which map within the short unique (US) region of the herpes simplex virus type 1 (HSV-1) genome. US has a total length of 12979 base pairs (1) and is extensively transcribed with approximately 94% of the total sequence present in cytoplasmic mRNAs and 79% of the total sequence considered to be protein coding. There are several examples of overlapping functions and multiple use of DNA sequence within this region. US contains 12 genes (1) which are expressed as 13 mRNAs. Two of these mRNAs are thought to arise from the same gene since they differ only slightly in the positions of their 5' ends and probably specify the same polypeptide. 11 of the 13 mRNAs are arranged into four nested families with unique 5' ends and common 3' co-termini. The other two mRNAs have unique 5' and 3' ends.

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