A processed pseudogene in an intron of the HLA-DPβ1 chain gene is a member of the ribosomal protein L32 gene family | Zendy

John A. T. Young | Zendy; John Trowsdale | Zendy

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A processed pseudogene in an intron of the HLA-DPβ1 chain gene is a member of the ribosomal protein L32 gene family

Author(s) -

John A. T. Young,

John Trowsdale

Publication year - 1985

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/13.24.8883

Subject(s) - biology , pseudogene , intron , genetics , gene , gene family , homology (biology) , complementary dna , ribosomal protein , genome , ribosomal rna , microbiology and biotechnology , ribosome , rna

A sequence in an intron of the human HLA-DP beta 1 gene was identified by its homology to the gene encoding ribosomal protein L32 (rpL32). It lacked introns indicating that it was derived from a processed rpL32 mRNA transcript. A human cDNA clone encoding rpL32 was isolated and compared to this human pseudogene and to several related mouse sequences, one of which is contained in an intron of the murine dihydrofolate reductase gene. Comparison of these sequences revealed that they were more related within species than between, suggesting that they became inserted in the genome after man and mouse diverged.

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