Alu sequences transcription inX. laevisoocytes: nuclear-cytoplasmic partitioning and evidence for 3′ end processing reactions | Zendy

Elda Perlino | Zendy; Giacomo Paonessa | Zendy; Gennaro Ciliberto | Zendy

Open Access

Alu sequences transcription inX. laevisoocytes: nuclear-cytoplasmic partitioning and evidence for 3′ end processing reactions

Author(s) -

Elda Perlino,

Giacomo Paonessa,

Gennaro Ciliberto

Publication year - 1985

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/13.23.8359

Subject(s) - biology , alu element , genetics , xenopus , transcription (linguistics) , cell nucleus , nucleus , rna polymerase iii , microbiology and biotechnology , gene , rna , genome , human genome , linguistics , philosophy , rna polymerase

A large Alu-family cluster in the 5' flanking region of a human alpha 1-acid glycoprotein gene has been identified and sequenced. Individual members microinjected into X. laevis oocytes are transcribed only when canonical box A and B components of the split pol III promoter are present. Alu transcripts accumulate in the nucleus. An unusually short Alu transcript, able to assume a stable secondary structure, undergoes a 3' end processing reaction similar to the one required for tRNA 3' end maturation.

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