Initiation of transcription of a mitochondrial tRNA gene duster inS.cerevisiae | Zendy

Claudio Palleschi | Zendy; Silvia Francisci | Zendy; Michele M. Bianchi | Zendy; Laura Frontali | Zendy

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Initiation of transcription of a mitochondrial tRNA gene duster inS.cerevisiae

Author(s) -

Claudio Palleschi,

Silvia Francisci,

Michele M. Bianchi,

Laura Frontali

Publication year - 1984

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/12.19.7317

Subject(s) - biology , genetics , transfer rna , mitochondrial dna , gene , saccharomyces cerevisiae , transcription (linguistics) , rna , linguistics , philosophy

In Saccharomyces cerevisiae most mitochondrial tRNA genes are clustered in a 9 kbp region between the cap and oxil genes. Polygenic transcripts of this region have been previously identified. A transcriptional initiation site at a TTATAAGTA box, located upstream from the tRNAcys gene, has now been detected by S1 mapping experiments and by the capping of primary transcripts. Results are consistent with the hypothesis that this box represents the initiation site for transcription of a cluster of tRNA genes, while the adjacent tRNA2thr is cotranscribed with the 21S rRNA. Results obtained with various strains are compared, and the efficiency of this sequence as a transcriptional initiation site in different mitochondrial contexts is discussed.

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