Correlation between suppressed meiotic recombination and the lack of DNA strand-breaks in the rRNA genes ofSaccharomyces cerevisiae | Zendy

Anders Høgset | Zendy; Tordis B. Øyen | Zendy

Open Access

Correlation between suppressed meiotic recombination and the lack of DNA strand-breaks in the rRNA genes ofSaccharomyces cerevisiae

Author(s) -

Anders Høgset,

Tordis B. Øyen

Publication year - 1984

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/12.18.7199

Subject(s) - rad52 , biology , homologous recombination , genetics , meiosis , saccharomyces cerevisiae , ectopic recombination , recombination , genetic recombination , homologous chromosome , non allelic homologous recombination , flp frt recombination , gene , dna repair , dna , mlh1 , mutant , chromosome , rad51 , dna mismatch repair

We have examined whether the suppressed homologous meiotic recombination within the rDNA of S. cerevisiae is reflected by a lack of possibly recombination-initiating strand-breaks in this part of the genome. Our findings indicate that bulk DNA in the ds-break repair deficient mutant rad52/rad52 accumulates a limited number of both ss- and ds-breaks during meiosis as compared to a RAD+/rad52 heterozygote. The rDNA-containing chromosome is however protected against these breaks, and thus this may be an explanation for the suppression of recombination in the rDNA. The fact that ds-breaks seem to be involved gives indirect support to the ds-break-repair model for recombination.

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