Codon usage can affect efficiency of translation of genes inEscherichia coli | Zendy

M K Robinson | Zendy; R.J. Lilley | Zendy; Stephen F. Little | Zendy; J.S. Emtage | Zendy; Geoffrey Yarranton | Zendy; P. Stephens | Zendy; A. Millican | Zendy; Michael A. W. Eaton | Zendy; G. O. Humphreys | Zendy

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Codon usage can affect efficiency of translation of genes inEscherichia coli

Author(s) -

M K Robinson,

R.J. Lilley,

Stephen F. Little,

J.S. Emtage,

Geoffrey Yarranton,

P. Stephens,

A. Millican,

Michael A. W. Eaton,

G. O. Humphreys

Publication year - 1984

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/12.17.6663

Subject(s) - division (mathematics) , library science , biology , computer science , mathematics , arithmetic

By inserting synthetic oligonucleotides into a highly expressed gene in E. coli it has been shown that unfavourable codon usage can reduce the maximum translation rate of a protein. However, in the case of the codon used (AGG), a significant effect on translation was only seen at very high transcription rates from a gene containing multiple copies of the unfavourable codon.

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