Open AccessEvolutionary divergence of genes for ornithine and aspartate carbamoyl-trasferases-complete sequence and mode of regulatio of theEscherichia coli argFgene; comparison ofargFwithargIandpyrB
Author(s) -
Françoise Van Vliet,
Raymond Cunin,
Annemie Jacobs,
Jacques Piette,
Daniel Gigot,
Marc Lauwereys,
André Pierard,
Nicolas Glansdorff
Publication year - 1984
Publication title -
nucleic acids research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 9.008
H-Index - 537
eISSN - 1362-4954
pISSN - 0305-1048
DOI - 10.1093/nar/12.15.6277
Subject(s) - biology , escherichia coli , gene , sequence (biology) , genetics , biochemistry , microbiology and biotechnology
The complete nucleotide sequence of argF is presented, together with that of an operator-constitutive mutant. ArgF is compared with the other gene coding for ornithine carbamoyltransferase (OTCase) in E. coli K-12, argI, and with pyrB, encoding the catalytic monomer of aspartate carbamoyltransferase (ATCase). ArgF and argI appear very closely related having emerged from a relatively recent ancestor gene. The relationship between OTCase and ATCase appears more distant. Nevertheless, the homology observed between the two proteins (mainly in the polar domain) suggests a common origin.