Open AccessHomology between two EBV early genes and HSV ribonudeotide reductase and 38K genes
Author(s) -
Toby J. Gibson,
Peter A. Stockwell,
Michelle Ginsburg,
Bart Barrell
Publication year - 1984
Publication title -
nucleic acids research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 9.008
H-Index - 537
eISSN - 1362-4954
pISSN - 0305-1048
DOI - 10.1093/nar/12.12.5087
Subject(s) - biology , gene , homology (biology) , genetics , ribonucleotide reductase , nucleic acid sequence , dna , peptide sequence , microbiology and biotechnology , protein subunit
Computer-matching of amino acid sequences predicted from the complete EBV DNA sequence against the known HSV gene sequences has revealed significant homology between two EBV reading frames and the HSV1 and HSV2 140K and 38K proteins which are associated with ribonucleotide reductase activity. The two genes are arranged tandemly as in HSV though it appears that, unlike HSV, the two mRNAs are not 3' co-terminal. We have mapped two promoters predicted from the DNA sequence for these genes and shown them to be transcribed at a similar stage in the virus life cycle to that of the HSV genes.