Open AccessTbe complete nudeotide sequences of the cloned hepatitis B vims DNA; subtype adr and adw
Author(s) -
Yoshitaka Ono,
Haruo Onda,
Reiko Sasada,
Koichi Igarashi,
Yukdo Sugino,
Kusuya Nishioka
Publication year - 1983
Publication title -
nucleic acids research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 9.008
H-Index - 537
eISSN - 1362-4954
pISSN - 0305-1048
DOI - 10.1093/nar/11.6.1747
Subject(s) - biology , virology , nucleotide , clone (java method) , nucleic acid sequence , hepatitis b virus , genome , dna , microbiology and biotechnology , hepadnaviridae , genetics , virus , gene
The complete nucleotide sequences of two different subtypes (adr and adw) of hepatitis B virus (HBV) DNA cloned in E. coli were determined. The sequence of the viral genome of the adr clone was 3188 nucleotides long, and that of the adw clone was 3200 nucleotides long. The adr and adw clones differed from the reported cloned ayw HBV DNA (3182 nucleotides long) in 11.2% and 10.0% of nucleotides, respectively. Heterogeneity of the HBV genome in the clones with the same subtype was observed.