Open AccessDialkylformamldines: depurination resistant N6-protecting group for deoxyadenosine
Author(s) -
Brian C. Froehler,
Mark D. Matteucci
Publication year - 1983
Publication title -
nucleic acids research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 9.008
H-Index - 537
eISSN - 1362-4954
pISSN - 0305-1048
DOI - 10.1093/nar/11.22.8031
Subject(s) - depurination , biology , deoxyadenosine , group (periodic table) , biochemistry , microbiology and biotechnology , genetics , dna , chemistry , organic chemistry
Sterically hindered N6-dialkylformamidine protected deoxyadenosine is more stable to acidic depurination than N6-benzoyldeoxyadenosine and is potentially a valuable protecting group in the synthesis of deoxyoligonucleotides.