The nucleotide sequence of replication and maintenance functions encoded by plasmid PSCl0l | Zendy

Glen Churchward | Zendy; Patrick Linder | Zendy; L. Caro | Zendy

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The nucleotide sequence of replication and maintenance functions encoded by plasmid PSCl0l

Author(s) -

Glen Churchward,

Patrick Linder,

L. Caro

Publication year - 1983

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/11.16.5645

Subject(s) - biology , replicon , plasmid , genetics , origin of replication , autonomously replicating sequence , nucleic acid sequence , dna replication , t dna binary system , direct repeat , gene , recombinant dna , vector (molecular biology) , genome

The nucleotide sequence of 1100bp around the origin of replication of the pSC101 plasmid has been determined. This segment of DNA is capable of replication in the presence of a helper plasmid. The sequence data reveal similarities between pSC101 and several other replicons. The origin of replication contains three direct repeats of an 18bp sequence associated with a segment exceptionally rich in A-T base pairs. A promotor that probably directs transcription of a gene encoding an essential plasmid replication function is associated with a region of extensive potential secondary structure. The sequence presented here includes the sequence of the par region involved in partitioning of plasmids at cell division.

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