Different levels of induction ofRecAprotein inE. coli(PQ 10) after treatment with two related carcinogens | Zendy

Bernard Salles | Zendy; Marie Claude E. Lang | Zendy; A.M. Freund | Zendy; Claude Paoletti | Zendy; M. Daune | Zendy; Robert P. Fuchs | Zendy

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Different levels of induction ofRecAprotein inE. coli(PQ 10) after treatment with two related carcinogens

Author(s) -

Bernard Salles,

Marie Claude E. Lang,

A.M. Freund,

Claude Paoletti,

M. Daune,

Robert P. Fuchs

Publication year - 1983

Publication title -

nucleic acids research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.008

H-Index - 537

eISSN - 1362-4954

pISSN - 0305-1048

DOI - 10.1093/nar/11.15.5235

Subject(s) - 2 acetylaminofluorene , biology , carcinogen , adduct , dna , escherichia coli , sos response , microbiology and biotechnology , immunoradiometric assay , biochemistry , genetics , dna repair , gene , enzyme , chemistry , radioimmunoassay , organic chemistry , microsome

By means of an immunoradiometric assay the induction of protein RecA in E. coli PQ 10 was measured after treatment by two related carcinogens. On an adduct basis N-Acetoxy-N-2-acetylaminofluorene was shown to induce the protein RecA at a similar level as U.V. On the other hand, N-hydroxy-N-2-aminofluorene shows only a poor induction capacity of the RecA protein. The difference in the SOS inducing potential of the aminofluorene and acetylaminofluorene adducts is discussed in relation to the major difference in the local conformational change the two adducts induce in DNA.

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