Open AccessRepetitive DNA sequences in the human corticotropin-β-lipotropin precursor gene region: Alu family members
Author(s) -
Toshihiko Tsukada,
Yumiko Watanabe,
Yoshikatsu Nakai,
Hiroo Imura,
Shigetada Nakanishi,
Shosaku Numa
Publication year - 1982
Publication title -
nucleic acids research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 9.008
H-Index - 537
eISSN - 1362-4954
pISSN - 0305-1048
DOI - 10.1093/nar/10.5.1471
Subject(s) - biology , alu element , repeated sequence , genetics , gene , southern blot , gene family , dna sequencing , dna , base pair , consensus sequence , nucleic acid sequence , microbiology and biotechnology , human genome , genome , peptide sequence
Repetitive DNA sequences in the human corticotropin-beta-lipotropin precursor gene region have been studied by blot hybridization analysis and DNA sequencing. Six repetitive sequences are present in this gene region; five of them are Alu family members with an approximate length of 300 base pairs, and the other consists of a portion of an Alu family sequence. Two of these Alu family members are located in the 5'-flanking region of the gene, and the remaining four within the intervening sequences. These Alu family sequences constitute inverted repeats in the intervening sequences as well as in the 5'-flanking region of the gene.