Open AccessStructural analysis of repetitive DNA sequences in the bovine corticotropin-β-tipotropin precursor gene region
Author(s) -
Yumiko Watanabe,
Toshihiko Tsukada,
Mitsue Notake,
Shigetada Nakanishi,
Shosaku Numa
Publication year - 1982
Publication title -
nucleic acids research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 9.008
H-Index - 537
eISSN - 1362-4954
pISSN - 0305-1048
DOI - 10.1093/nar/10.5.1459
Subject(s) - biology , repeated sequence , tandem repeat , dna , genetics , base pair , bovine genome , nucleic acid sequence , gene , homology (biology) , microbiology and biotechnology , direct repeat , genome , homologous chromosome
Repetitive DNA sequences in the bovine corticotropin-beta-lipotropin precursor gene region have been mapped and subjected to nucleotide sequence analysis. Two of the four repetitive DNA segments found are located in the 5'-flanking region, and one each within the intervening sequences. Each repetitive DNA segment contains one to three highly homologous unit sequences with an approximate length of 120 base pairs. All the unit sequences are flanked on the 3' side by tandem repeats. There are about 10(5) copies of the repetitive DNA in the bovine genome. Comparison of the bovine repetitive sequences with those of other mammalian species reveals the presence of a homologous segment of approximately 40 base pairs. This segment and the region preceding it in the bovine repetitive DNA exhibit sequence homology with the region encompassing the origin of DNA replication in papovaviruses.