Open AccessImmunoglobulin switch region-like sequences inDrosophila melanogaster
Author(s) -
Yasuhiko Sakoyama,
Yoshio Yaoita,
Tasuku Honjo
Publication year - 1982
Publication title -
nucleic acids research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 9.008
H-Index - 537
eISSN - 1362-4954
pISSN - 0305-1048
DOI - 10.1093/nar/10.14.4203
Subject(s) - biology , drosophila melanogaster , genetics , drosophilidae , nucleic acid sequence , drosophila (subgenus) , dna , dna sequencing , gene
We found immunoglobulin switch (S) region-like sequences in DNAs of wide variety of organisms including sea urchin, yeast and Drosophila that do not produce immunoglobulins. DNA fragments carrying Smu-like sequences were cloned from Drosophila and the nucleotide sequence of a clone is almost identical to that of the mouse Smu region. Restriction fragments of Drosophila Smu-like sequences and their flanking regions seem to vary among Drosophila species. Possible evolutionary significance of the Smu-like sequence in invertebrates was discussed.