Open AccessImpact of hypoxia on DNA repair and genome integrity
Author(s) -
Alanna R. Kaplan,
Peter M. Glazer
Publication year - 2019
Publication title -
mutagenesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.723
H-Index - 91
eISSN - 1464-3804
pISSN - 0267-8357
DOI - 10.1093/mutage/gez019
Subject(s) - dna repair , hypoxia (environmental) , genome instability , biology , cancer research , base excision repair , dna damage , dna , homologous recombination , dna mismatch repair , genetics , bioinformatics , chemistry , organic chemistry , oxygen
Hypoxia is a hallmark of the tumour microenvironment with profound effects on tumour biology, influencing cancer progression, the development of metastasis and patient outcome. Hypoxia also contributes to genomic instability and mutation frequency by inhibiting DNA repair pathways. This review summarises the diverse mechanisms by which hypoxia affects DNA repair, including suppression of homology-directed repair, mismatch repair and base excision repair. We also discuss the effects of hypoxia mimetics and agents that induce hypoxia on DNA repair, and we highlight areas of potential clinical relevance as well as future directions.