Accelerated Progression of Disseminated Coccidioidomycosis Following SARS-CoV-2 Infection: A Case Report | Zendy

Daniel S. Krauth | Zendy; Christina Jamros | Zendy; Shayna C Rivard | Zendy; Niels Olson | Zendy; Ryan C. Maves | Zendy

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Accelerated Progression of Disseminated Coccidioidomycosis Following SARS-CoV-2 Infection: A Case Report

Author(s) -

Daniel S. Krauth,

Christina Jamros,

Shayna C Rivard,

Niels Olson,

Ryan C. Maves

Publication year - 2021

Publication title -

military medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.442

H-Index - 67

eISSN - 1930-613X

pISSN - 0026-4075

DOI - 10.1093/milmed/usab132

Subject(s) - medicine , covid-19 , virology , pandemic , betacoronavirus , outbreak , pathology , disease , infectious disease (medical specialty)

We describe a patient with subclinical coccidioidomycosis who experienced rapid disease dissemination shortly after SARS-CoV-2 infection, suggesting host immune response dysregulation to coccidioidomycosis by SARS-CoV-2. We hypothesize that disrupted cell-mediated signaling may result after SARS-CoV-2 infection leading to functional exhaustion and CD8+ T-cell senescence with impairment in host cellular response to Coccidioides infection.

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