Open AccessHemophagocytic lymphohistiocytosis associated with Epstein–Barr virus infection: case report and literature review
Author(s) -
Saeed O. Bahabri,
Ammar Al Rikabi,
Amjad O. Alshammari,
Sara I Alturkestany
Publication year - 2019
Publication title -
journal of surgical case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.14
H-Index - 3
ISSN - 2042-8812
DOI - 10.1093/jscr/rjy096
Subject(s) - medicine , hepatosplenomegaly , hemophagocytic lymphohistiocytosis , laparotomy , hemophagocytosis , pneumoperitoneum , perforation , epstein–barr virus infection , epstein–barr virus , surgery , virus , pediatrics , pathology , immunology , pancytopenia , laparoscopy , bone marrow , disease , materials science , punching , metallurgy
Hemophagocytic lymphohistiocytosis (HLH) is rare and life threatening syndrome. There are only a few reported cases of HLH with GI symptoms. We describe the case of an 18 months old boy who presented with a history of fever for 40 days, abdominal distention and hepatosplenomegaly. Abdominal x-ray showed a pneumoperitoneum. Urgent laparotomy was done which revealed an isolated cecal perforation. The histopathological findings in the subsequent resected bowel was HLH with evidence of positive EBV Barr infection.