Protective effects of new aryl sulfone derivatives against radiation-induced hematopoietic injury | Zendy

Jian Cao | Zendy; Hongyan Li | Zendy; Renbin Yuan | Zendy; Yinping Dong | Zendy; Jing Wu | Zendy; Meifang Wang | Zendy; Deguan Li | Zendy; Hongqi Tian | Zendy; Hui Dong | Zendy

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Protective effects of new aryl sulfone derivatives against radiation-induced hematopoietic injury

Author(s) -

Jian Cao,

Hongyan Li,

Renbin Yuan,

Yinping Dong,

Jing Wu,

Meifang Wang,

Deguan Li,

Hongqi Tian,

Hui Dong

Publication year - 2020

Publication title -

journal of radiation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.643

H-Index - 60

eISSN - 1349-9157

pISSN - 0449-3060

DOI - 10.1093/jrr/rraa009

Subject(s) - haematopoiesis , sulfone , aryl , reactive oxygen species , chemistry , apoptosis , dna damage , pharmacology , cancer research , stem cell , biology , biochemistry , dna , microbiology and biotechnology , organic chemistry , alkyl

The hematopoietic system is sensitive to radiation. In this research, new aryl sulfone derivatives (XH-201 and XH-202) containing a nitrogen heterocycle were designed and synthesized and their radio-protective efficacies with regard to the hematopoietic system were evaluated. XH-201 administration significantly increased the survival rate of mice after 8.0 Gy total body irradiation (TBI). The results showed that XH-201 treatment not only increased the white blood cells, platelets counts and the percentage of hematopoietic progenitor cells and hematopoietic stem cells in mice exposed to 4.0 Gy TBI but also decreased DNA damage, as determined by flow cytometric analysis of histone H2AX phosphorylation. In addition, our data demonstrated that XH-201 decreased the mitochondrial reactive oxygen species (ROS) levels in hematopoietic cells. Overall, these data suggest that XH-201 is beneficial for the protection of the hemoatopoietic system against radiation-induced injuries.

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