Evaluation of a New Clinical Endpoint for Moderate to Severe Influenza Disease in Children: A Prospective Cohort Study | Zendy

Suchitra Rao | Zendy; Emad Yanni | Zendy; Angela Moss | Zendy; Molly M. Lamb | Zendy; Anne Schuind | Zendy; Rafik Bekkat-Berkani | Zendy; Bruce L. Innis | Zendy; Jillian M. Cotter | Zendy; Rakesh D. Mistry | Zendy; Edwin J. Asturias | Zendy

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Evaluation of a New Clinical Endpoint for Moderate to Severe Influenza Disease in Children: A Prospective Cohort Study

Author(s) -

Suchitra Rao,

Emad Yanni,

Angela Moss,

Molly M. Lamb,

Anne Schuind,

Rafik Bekkat-Berkani,

Bruce L. Innis,

Jillian M. Cotter,

Rakesh D. Mistry,

Edwin J. Asturias

Publication year - 2019

Publication title -

journal of the pediatric infectious diseases society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.269

H-Index - 31

eISSN - 2048-7207

pISSN - 2048-7193

DOI - 10.1093/jpids/piz075

Subject(s) - medicine , emergency department , pediatrics , prospective cohort study , clinical endpoint , confidence interval , respiratory tract infections , clinical trial , respiratory system , psychiatry

A moderate to severe (M/S) influenza clinical endpoint has been proposed in children, defined as fever >39°C, otitis media, lower respiratory tract infection, or serious extrapulmonary manifestations. The objective of the study was to evaluate the M/S measure against clinically relevant outcomes including hospitalization, emergency room visits, antimicrobial use, and child/parental absenteeism.

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