Open AccessEvaluation of a New Clinical Endpoint for Moderate to Severe Influenza Disease in Children: A Prospective Cohort Study
Author(s) -
Suchitra Rao,
Emad Yanni,
Angela Moss,
Molly M. Lamb,
Anne Schuind,
Rafik Bekkat-Berkani,
Bruce L. Innis,
Jillian M. Cotter,
Rakesh D. Mistry,
Edwin J. Asturias
Publication year - 2019
Publication title -
journal of the pediatric infectious diseases society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 31
eISSN - 2048-7207
pISSN - 2048-7193
DOI - 10.1093/jpids/piz075
Subject(s) - medicine , emergency department , pediatrics , prospective cohort study , clinical endpoint , confidence interval , respiratory tract infections , clinical trial , respiratory system , psychiatry
A moderate to severe (M/S) influenza clinical endpoint has been proposed in children, defined as fever >39°C, otitis media, lower respiratory tract infection, or serious extrapulmonary manifestations. The objective of the study was to evaluate the M/S measure against clinically relevant outcomes including hospitalization, emergency room visits, antimicrobial use, and child/parental absenteeism.