Open AccessProspective Cohort Study of Next-Generation Sequencing as a Diagnostic Modality for Unexplained Encephalitis in Children
Author(s) -
Julia C. Haston,
Christina A. Rostad,
Robert C. Jerris,
Sarah Sarvis Milla,
Courtney McCracken,
Catherine Pratt,
Michael R. Wiley,
Karla Prieto,
Gustavo Palacios,
Andi L. Shane,
Anita K. McElroy
Publication year - 2019
Publication title -
journal of the pediatric infectious diseases society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 31
eISSN - 2048-7207
pISSN - 2048-7193
DOI - 10.1093/jpids/piz032
Subject(s) - medicine , encephalitis , prospective cohort study , etiology , cohort , serology , virology , immunology , virus , antibody
Encephalitis is an inflammatory condition of the brain associated with long-term neurologic sequelae and even death in children. Although viruses are often implicated, an etiology is not identified in the majority of cases. Metagenomics-based next-generation sequencing (mNGS) is a high-throughput sequencing technique that can enhance the detection of novel or low-frequency pathogens.